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Large-scale synthesis

  • Obtain high purity DNA and RNA oligos in bulk quantities with competitive pricing and turnaround times
  • Consult and collaborate with our experts to determine the best solutions for your projects from pilot to commercial-scale production
  • Focus on commercialization efforts and allow us to manufacture to your exact specifications with custom QC, processing, and documentation

Manufacturing capabilities

Numerous collaborations with our customers have enabled us to optimize our manufacturing processes and platforms for bulk synthesis of various types of oligos. Our large-scale capabilities range from standard, unmodified oligos to highly complex oligos for in vivo, high-throughput, diagnostic, and other commercial applications. You can acquire milligram to gram quantities of highly pure nucleic acids, including aptamers, ribozymes, miRNAs and siRNAs, next generation sequencing adapters, PCR primers, and dual-labelled probes.

Additional features of our large-scale offerings include:

  • Final yields from 25 mg to 10 g
  • Standard DNA and RNA bases, modified bases, chemical modifications, linkers, and fluorophores
  • Unmodified DNA lengths between 4–100 bases
  • Unmodified RNA lengths between 4–70 bases
  • GMP manufacturing available for components used in molecular diagnostic assays
  • Quick turnaround times with delivery in as few as 10 business days
Due to unprecedented demand for our large-scale synthesis services, we are experiencing longer than usual turnaround times. Please contact us to discuss your needs and to receive more accurate timelines.

Additional services

In addition to using industry-leading oligos, when you work with our team of large-scale experts you will benefit from a variety of personalized services. These include:

  • Confidential, application-specific guidance for your transition from small- to large-scale production
  • Flexible ordering methods
  • Custom purification options and purity specifications
  • Formulation services for the creation of oligo pools, primer mixes, assays, and duplexes
  • Custom vialing and plating options with consistent or variable fill sizes
  • Verification and release of product compliance before shipment
  • Hard-copy analytical QC documentation and certificates of analysis

To learn more about these individual services, click here.

PrimerQuest™ Tool

Allows highly customized designs for PCR primers and qPCR assays

OligoAnalyzer™ tool

Identify oligonucleotide properties, including melting temperature, hairpins, dimers and mismatches

UNAFold tool

Perform secondary structure analysis

Dilution Calculator

Find the volume needed to dilute your oligo stock to a lower concentration

Resuspension Calculator

Find the volume needed to resuspend a dry oligo to a desired concentration

GMP

Our GMP products and services satisfy the elevated quality and documentation requirements of clinical and molecular diagnostic applications. To learn more about our GMP capabilities, click here.